The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2023

Filed:

Jun. 26, 2020
Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Johanna Bobrow, Somerville, MA (US);

Todd Thorsen, Carlisle, MA (US);

David Walsh, Boston, MA (US);

Christina Zook, Tewksbury, MA (US);

Min Jae Song, Laytonsville, MD (US);

Marc Ferrer-Alegre, Potomac, MD (US);

Sam Michael, Germantown, MD (US);

Yen-Ting Tung, Derwood, MD (US);

Molly Elizabeth Boutin, Troy, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/32 (2006.01); B01L 3/00 (2006.01); C12M 1/12 (2006.01); C12M 1/00 (2006.01);
U.S. Cl.
CPC ...
C12M 23/12 (2013.01); B01L 3/502715 (2013.01); B01L 3/502738 (2013.01); C12M 23/40 (2013.01); C12M 25/14 (2013.01); C12M 29/10 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0861 (2013.01);
Abstract

An in vitro tissue plate may include a well plate, a fluidic plate disposed on a bottom surface of the well plate, and a media manifold disposed on a bottom surface of the fluidic plate. The well plate may have at least two wells, including a tissue well and a waste well. The fluid plate may include a fluid channel extending between and fluidly connecting the tissue well to the waste well. The media manifold may include a one or more media outlets fluidly connected to the fluid channel. A tissue layer may be deposited in the tissue well. The tissue layer may include human cells such as neurovascular cells.


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