The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2023
Filed:
Sep. 10, 2019
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Ping Tsui, Gaithersburg, MD (US);
Martin Borrok, Gaithersburg, MD (US);
William Dall'Acqua, Gaithersburg, MD (US);
Yanli Wu, Gaithersburg, MD (US);
Nurten Beyaz-Kavuncu, Gaithersburg, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 16/40 (2006.01); C07K 16/10 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 47/68 (2017.08); C07K 16/00 (2013.01); C07K 16/005 (2013.01); C07K 16/1027 (2013.01); C07K 16/2887 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention provides molecules, including proteins, more particularly, immunoglobulins whose in vivo half-lives are altered (increased or decreased) by the presence of an IgG constant domain, or FcRn binding fragment thereof (e.g., an Fc region or hinge-Fc region) (e.g., from a human IgG, e.g., human IgG1), that have modifications of one or more of amino acid residues in at least the CH3 domain.