The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2023
Filed:
Jan. 31, 2023
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Toshiyuki Morichika, Tokyo, JP;
Daisuke Kameoka, Tokyo, JP;
Yoshimi Imaeda, Tokyo, JP;
Terutoshi Maeda, Tokyo, JP;
Oliver Boris Stauch, Freiburg, DE;
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Abstract
The problem to be solved is to provide a humanized anti-IL-6 receptor antibody AMA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.