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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11766469 B1

PDFFull Text
Date of Patent:
Sep. 26, 2023

Filed:

Nov. 02, 2020

Q-peptide hydrogel promotes immune modulation and macrophage differentiation

Applicant:

Quthero, Inc., Miami, FL (US);

Inventors:

Serena Mandla, Toronto, CA;

Milica Radisic, Toronto, CA;

Assignee:

QUTHERO, INC., Miami, FL (US);

Attorney:

Ridout & Maybee LLP

Primary Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
A61K 38/08 (2019.01); A61K 38/16 (2006.01); A61K 38/00 (2006.01); A61P 17/02 (2006.01); A61F 13/00 (2006.01); A61K 9/70 (2006.01); A61K 9/14 (2006.01); A61K 38/18 (2006.01); C12N 5/077 (2010.01); A61K 47/61 (2017.01); A61K 9/06 (2006.01); G01N 33/68 (2006.01); A61K 47/42 (2017.01);
U.S. Cl.
CPC ...
A61K 38/1891 (2013.01); A61K 9/06 (2013.01); A61K 9/14 (2013.01); A61K 9/70 (2013.01); A61K 9/7007 (2013.01); A61K 9/7015 (2013.01); A61K 38/08 (2013.01); A61K 47/42 (2013.01); A61K 47/61 (2017.08); A61P 17/02 (2018.01); C12N 5/0669 (2013.01); G01N 33/6893 (2013.01); C12N 2501/17 (2013.01);
Abstract

The present invention examines the interaction between an angiopoietin-1 mimetic peptide, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine (SEQ ID NO: 1)) immobilized to a collagen-chitosan hydrogel, and murine bone marrow derived macrophages. When macrophages were cultured in the presence of the peptide conjugated to a hydrogel, both pro-inflammatory and anti-inflammatory cytokines were produced, in contrast to the application of soluble peptide which elicited minimal cytokine secretion. This indicates a unique macrophage polarization with covalently immobilized peptide hydrogels, which can be beneficial in the context of the wound microenvironment.

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