The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2023

Filed:

Jul. 11, 2018
Applicant:

Kyungpook National University Industry-academic Cooperation Foundation, Daegu, KR;

Inventors:

Jae Sung Bae, Daegu, KR;

Hee Kyung Jin, Daegu, KR;

Ju Youn Lee, Daegu, KR;

Min Hee Park, Daegu, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/661 (2006.01); A61K 47/69 (2017.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/661 (2013.01); A61K 47/6917 (2017.08); A61P 25/28 (2018.01);
Abstract

The present invention relates to a novel use for HDL-ApoM-S1P (a high density lipoprotein in which apolipoprotein M is impregnated with sphingosine-1-phosphate), and more particularly, to using HDL-ApoM-S1P to prevent, improve, or treat degenerative brain disorders (in particular, Alzheimer's disease), cognitive disorders, learning disabilities, and memory disorders, and using HDL-ApoM-S1P to improve cognitive ability, learning ability, and memory. The HDL-ApoM-S1P according to the present invention not only alleviates neuroinflammation but also significantly exhibits improvement effects of cognitive disorder, learning disability, and memory disorder with respect to individuals suffering from degenerative brain disorders (in particular, Alzheimer's disease), and exhibits an effect of greatly reducing amyloid beta and tau deposition. Moreover, increased HDL-ApoM-S1P in the body also has an excellent effect of improving the cognitive, learning, and memory abilities of non-disabled individuals.


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