IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11766420 B1

PDFFull Text
Date of Patent:
Sep. 26, 2023

Filed:

May. 03, 2016

Application of pi4kiiia protein and related membrane protein complex in treating alzheimer's disease

Applicant:

Jiangsu Nuo-beta Pharmaceutical Technology Co., Ltd., Nantong Jiangsu, CN;

Inventors:

Fude Huang, Shanghai, CN;

Xiao Zhang, Shanghai, CN;

Wenan Wang, Shanghai, CN;

Le Zhang, Shanghai, CN;

Lixiang Jiang, Shanghai, CN;

Tong Zhu, Shanghai, CN;

Haiyan Liu, Shanghai, CN;

Yudong Zhou, Zhejiang, CN;

Yang He, Zhejiang, CN;

Wanguo Wei, Shanghai, CN;

Assignee:

JIANGSU NUO-BETA PHARMACEUTICAL TECHNOLOGY CO. LTD., Nantong, CN;

Attorney:

Goodwin Procter LLP

Primary Examiner:

Adam Weidner

Int. Cl.
CPC ...
A61K 31/285 (2006.01); A61K 31/341 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/404 (2006.01); A61K 31/42 (2006.01); A61K 31/4406 (2006.01); A61K 31/47 (2006.01); A61K 31/5375 (2006.01); A61K 31/538 (2006.01); A61K 31/54 (2006.01); A61K 38/45 (2006.01); A61K 38/00 (2006.01); C07K 14/395 (2006.01); C07K 14/415 (2006.01); C07K 16/12 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
A61K 31/285 (2013.01); A61K 31/341 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61K 31/42 (2013.01); A61K 31/4406 (2013.01); A61K 31/47 (2013.01); A61K 31/538 (2013.01); A61K 31/5375 (2013.01); A61K 31/54 (2013.01); A61K 38/45 (2013.01); C07K 14/395 (2013.01); C07K 14/415 (2013.01); C07K 16/1203 (2013.01); C07K 16/18 (2013.01); C07K 16/40 (2013.01); C12Y 207/01067 (2013.01); A61K 38/00 (2013.01);
Abstract

The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIIIα enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIIIα protein kinase activity reduces the accumulation of Aβwithin neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIIIα inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether Aβ secretion by nerve cells is promoted or not.

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