The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Feb. 04, 2016
Bristol-myers Squibb Company, Princeton, NJ (US);
Roche Innovation Center Copenhagen A/s, Horsholm, DK;
Richard E. Olson, Cambridge, MA (US);
Angela M. Cacace, Haddam Neck, CT (US);
Peter Hagedorn, Horsholm, DK;
Anja Mølhart Høg, Hillerød, DK;
Niels Fisker Nielsen, Kgs. Lyngby, DK;
Dong LI, Cambridge, MA (US);
Jeffrey M. Brown, Medway, MA (US);
Stephen E. Mercer, Cambridge, MA (US);
Marianne Lerbech Jensen, Køge, DK;
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Abstract
The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.