The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Nov. 16, 2020
Applicant:
Eisai R&d Management Co., Ltd., Tokyo, JP;
Inventors:
Lihua Yu, Acton, MA (US);
Kian Huat Lim, Burlington, MA (US);
Jacob D. Feala, Franklin, MA (US);
Silvia Buonamici, Boston, MA (US);
Yoshiharu Mizui, Boston, MA (US);
Peter G. Smith, Arlington, MA (US);
Ping Zhu, Boxborough, MA (US);
Eunice Sun Park, Arlington, MA (US);
Michael W. Seiler, Watertown, MA (US);
Marco Peter Fekkes, Waltham, MA (US);
Assignee:
Eisai R&D Management Co., Ltd., Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); A61P 35/00 (2006.01); A61K 31/4545 (2006.01); A61K 31/495 (2006.01); A61K 31/55 (2006.01); C12Q 1/02 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6841 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/4545 (2013.01); A61K 31/495 (2013.01); A61K 31/55 (2013.01); A61P 35/00 (2018.01); C12Q 1/025 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6841 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.