The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Apr. 08, 2022
Applicant:
Arsenal Biosciences, Inc., South San Francisco, CA (US);
Inventors:
Xinying Zheng, San Jose, CA (US);
Brendan Galvin, San Bruno, CA (US);
Somya Khare, Saratoga, CA (US);
Aaron Cooper, Berkeley, CA (US);
Michelle Nguyen, San Francisco, CA (US);
Anzhi Yao, San Francisco, CA (US);
Assignee:
ARSENAL BIOSCIENCES, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); C12N 15/11 (2006.01); C12N 9/22 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1136 (2013.01); A61K 35/17 (2013.01); C12N 5/0636 (2013.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01); C12N 15/85 (2013.01); C12N 2310/20 (2017.05);
Abstract
Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.