IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11759528 B1

PDFFull Text
Date of Patent:
Sep. 19, 2023

Filed:

Dec. 07, 2018

Peg linker and ligand drug conjugate

Applicant:

Jenkem Technology Co., Ltd. (Beijing), Beijing, CN;

Inventors:

Yanping Song, Beijing, CN;

Wen Li, Beijing, CN;

Jinliang Wang, Beijing, CN;

Yan Liu, Beijing, CN;

Kun Zheng, Beijing, CN;

Meina Lin, Beijing, CN;

Zhen Wei, Beijing, CN;

Zewang Feng, Beijing, CN;

Xuan Zhao, Beijing, CN;

Assignee:

JENKEM TECHNOLOGY CO., LTD. (BEIJING), Beijing, CN;

Attorneys:

FLENER IP & BUSINESS LAW

Zareefa B. Flener

Primary Examiner:

Karl J Puttlitz

Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 31/4745 (2006.01); C08G 65/48 (2006.01); A61P 37/02 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); C08G 65/334 (2006.01); C07C 69/708 (2006.01); A61K 47/60 (2017.01); C08G 65/333 (2006.01); A61K 31/436 (2006.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); C07C 59/125 (2006.01); C07C 247/04 (2006.01); C07C 309/65 (2006.01); C07D 207/452 (2006.01); C07D 207/46 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6855 (2017.08); A61K 31/436 (2013.01); A61K 31/4745 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61K 47/60 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6883 (2017.08); A61P 31/00 (2018.01); A61P 35/00 (2018.01); A61P 37/02 (2018.01); C07C 59/125 (2013.01); C07C 69/708 (2013.01); C07C 247/04 (2013.01); C07C 309/65 (2013.01); C07D 207/452 (2013.01); C07D 207/46 (2013.01); C07K 16/2809 (2013.01); C07K 16/32 (2013.01); C08G 65/334 (2013.01); C08G 65/3332 (2013.01); C08G 65/3344 (2013.01); C08G 65/33303 (2013.01); C08G 65/33317 (2013.01); C08G 65/48 (2013.01); C07K 2317/94 (2013.01);
Abstract

A PEG linker as represented by formula (I), wherein n and m are respectively an integer from 1 to 7, providing the PEG linker with 1 to 49 linking sites. A ligand drug conjugate as represented by formula (II). The conjugate uses the PEG linker to increase a drug loading capacity and drug loading diversity, thereby improving pharmaceutical efficacy.Y1-PEG1-{R-PEG2-{Y4}}  (I)TM-{R-PEG1-{R-PEG2-{R-A'-drug}}}  (II)

Find Patent Forward Citations

Loading…