The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 19, 2023

Filed:

May. 25, 2018
Applicants:

Medimmune, Llc, Gaithersburg, MD (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Ronald James Christie, Gaithersburg, MD (US);

Changshou Gao, Gaithersburg, MD (US);

Andre Henri St. Amant, Oakland, CA (US);

Javier Read de Alaniz, Oakland, CA (US);

Assignees:

MedImmune, LLC, Gaithersburg, MD (US);

The Regents Of The University Of California, Oakland, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 47/69 (2017.01); C07C 271/22 (2006.01); C07D 207/46 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6811 (2017.08); A61K 47/6889 (2017.08); A61K 47/6923 (2017.08); C07C 271/22 (2013.01); C07D 207/46 (2013.01); C07C 2601/10 (2017.05); C07C 2602/50 (2017.05);
Abstract

The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.


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