The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Mar. 08, 2022
Centro DE Ingeniería Genética Y Biotecnología, Havana, CU;
Julio César Aguilar Rubido, Havana, CU;
Yadira Lobaina Mato, Havana, CU;
Enrique Iglesias Perez, Havana, CU;
Eduardo Pentón Arias, Havana, CU;
Gerardo Enrique Guillén Nieto, Havana, CU;
Jorge Agustin Aguiar Santiago, Havana, CU;
Sonia Gonzalez Blanco, Havana, CU;
Jorge Valdes Hernandez, Havana, CU;
Mariela Vazquez Catillo, Havana, CU;
CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, Havana, CU;
Abstract
This invention reveals the pharmaceutical composition that includes the surface antigen (HBsAg) of the hepatitis B virus (HBV) and the antigen of the nucleocapsid (or core, HBcAg) of the same virus. The HBcAg of this composition contains messenger ribonucleic acid (mRNA) at a proportion of over 45% of the total amount of ribonucleic acid (RNA) in this antigen. Because of the changes in the constitution of the antigens forming it, the composition of the invention is useful for the prevention or treatment of chronic hepatitis B. It also covers the use of this pharmaceutical composition in the production of a drug for immuno-prophylaxis or immunotherapy against HBV infection, and its use to increase the immune response against an additional antigen that is co-administered with the mixture of these antigens.