The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Apr. 18, 2018
Cedars-sinai Medical Center, Los Angeles, CA (US);
Capricor, Inc, Beverly Hills, CA (US);
Eduardo Marban, Los Angeles, CA (US);
Mark Amin Aminzadeh, Los Angeles, CA (US);
Russell Rogers, Los Angeles, CA (US);
Jennifer Moseley, Los Angeles, CA (US);
Luis Rodriguez-Borlado, Los Angeles, CA (US);
Saravana Kanagavelu, Los Angeles, CA (US);
Christopher Stewart Sakoda, Los Angeles, CA (US);
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Capricor, Inc., Beverly Hills, CA (US);
Abstract
Some embodiments provide a method of treating skeletal muscular myopathy, e.g., Duchenne muscular dystrophy (DMD), with cardiosphere-derived cells (CDCs), wherein a therapeutically effective amount of CDCs is delivered to a targeted dystrophic skeletal muscle. Some embodiment enable delivery of a therapeutically effective amount of CDCs via intramuscular injection directly at a skeletal muscle or systemic administration, intravenous injection, in a single dose or multiple doses, to treat a targeted dystrophic skeletal muscle. Some embodiments provide a method for improving exercise capabilities in DMD patients. Additional embodiments relate to exosome, mediated transfer of noncoding RNAs ameliorates Duchenne muscular dystrophy by restoring dystrophin in heart and skeletal muscle. Delivery of noncoding RNA species found in CDC-derived exosomes mimics the ability of CDCs and CDC-derived exosomes to increase dystrophin protein levels.