The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 19, 2023

Filed:

Jul. 08, 2020
Applicant:

Chemocentryx, Inc., Mountain View, CA (US);

Inventors:

Xi Chen, East Palo Alto, CA (US);

Pingchen Fan, Fremont, CA (US);

Yandong Li, San Diego, CA (US);

Jay P. Powers, Pacifica, CA (US);

Viengkham Malathong, Mountain View, CA (US);

Sreenivas Punna, Sunnyvale, CA (US);

Hiroko Tanaka, Mountain View, CA (US);

Penglie Zhang, Foster City, CA (US);

Dean Dragoli, Los Altos, CA (US);

Assignee:

CHEMOCENTRYX, INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4178 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 45/06 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/4155 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4178 (2013.01); A61K 31/4155 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.


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