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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11759437 B1

PDFFull Text
Date of Patent:
Sep. 19, 2023

Filed:

Sep. 22, 2017

Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases

Applicant:

The University of Hong Kong, Hong Kong, CN;

Inventors:

Song Eng Kathryn Cheah, Hong Kong, CN;

Danny Chan, Hong Kong, CN;

Cheng Wang, Hong Kong, CN;

Cheuk Wing Wilson Chan, Hong Kong, CN;

Assignee:

The University of Hong Kong, Hong Kong, CN;

Attorney:

Law Offices of Albert Wai-Kit Chan, PLLC

Primary Examiner:

Sahar Javanmard

Int. Cl.
CPC ...
A61K 31/136 (2006.01); A61K 31/165 (2006.01); A61P 19/08 (2006.01); C07C 235/14 (2006.01); C07C 211/29 (2006.01); C07C 235/20 (2006.01); A61P 19/00 (2006.01); A61K 31/519 (2006.01); A61P 3/08 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61K 31/47 (2006.01); A61K 31/4965 (2006.01);
U.S. Cl.
CPC ...
A61K 31/136 (2013.01); A61K 31/165 (2013.01); A61K 31/47 (2013.01); A61K 31/4965 (2013.01); A61K 31/519 (2013.01); A61P 3/08 (2018.01); A61P 19/00 (2018.01); A61P 19/08 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07C 211/29 (2013.01); C07C 235/14 (2013.01); C07C 235/20 (2013.01);
Abstract

The present invention describes a method of preventing, ameliorating and/or treating disorders or diseases associated with the integrated stress response (ISR) involving the p-eIF2α pathway arising from various cellular stresses such as oxidative stress, hypoxia and ER stress, chronic or prolonged bio-mechanical stress. In one embodiment, the present invention provides a method which prevents or alleviates aberrant cell differentiation that is caused by the activation of the integrated stress response and thereby prevents or alleviates conditions, disorders or diseases resulting therefrom. In one embodiment, ISR-associated diseases subject to the present invention include but are not limited to skeletal disorders including disc degeneration, MCDS and other skeletal dysplasias, cancers, inflammatory diseases, diabetes, fibrosis, obesity and neurodegenerative diseases. In another embodiment, the present invention provides a method of using a p-eIF2α-modulator for the prevention or treatment of conditions, disorders or diseases described herein.

Find Patent Forward Citations

Cheah, Song Eng Kathryn. (2023). Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases (U.S. Patent No. 11759437). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11759437

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