The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Nov. 09, 2016
The University of British Columbia, Vancouver, CA;
Steven Samuel Plotkin, Vancouver, CA;
The University of British Columbia, Vancouver, CA;
Abstract
Methods predict candidate epitopes in a protein by: providing a conformational sampling engine; obtaining a model of a protein suitable for use with the conformational sampling engine and comprising a native structure; applying a collective coordinate bias to the protein model, the collective coordinate bias causing the conformational sampling engine to in turn force the protein model to at least partially unfold from its native structure to an updated structure, wherein the collective coordinate bias is applied globally to at least a substantial portion of the protein model and is impartial as to where, within the substantial portion of the protein model, unfolding occurs; and analyzing the updated structure to identify one or more candidate epitopes, where the one or more candidate epitopes exhibit indicia of localized unfolding.