The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2023

Filed:

Aug. 25, 2021
Applicant:

Syros Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Jason J. Marineau, Franklin, MA (US);

Peter B. Rahl, Natick, MA (US);

Kevin Sprott, Needham, MA (US);

Stephane Ciblat, Montreal, CA;

Boubacar Sow, Saint-Laurent, CA;

Robin Larouche-Gauthier, Montreal, CA;

Lauren Berstler, Somerville, MA (US);

Christopher Roberts, Belmont, MA (US);

Yi Zhang, Belmont, MA (US);

Francis Beaumier, Mont-Saint-Hilaire, CA;

Luce Lépissier, Montreal, CA;

Assignee:

Syros Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); A61P 35/00 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61P 35/00 (2018.01); C07D 495/04 (2013.01);
Abstract

The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.


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