The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Apr. 22, 2021
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Loyola University of Chicago, Chicago, IL (US);
Wenwei Huang, Rockville, MD (US);
Hao Li, Rockville, MD (US);
Wei Sun, Germantown, MD (US);
Xiuli Huang, Potomac, MD (US);
Paresma R. Patel, Rockville, MD (US);
Hangmao Sun, Germantown, MD (US);
Wei Zheng, Potomac, MD (US);
Xiao Lu, Rockville, MD (US);
Philip E. Sanderson, Bethesda, MD (US);
Myunghoon Kim, Olympia, WA (US);
Meghan J. Orr, Nashville, IL (US);
Gregory J. Tawa, Doylestown, PA (US);
Kim C. Williamson, Bethesda, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Loyola University of Chicago, Chicago, IL (US);
Abstract
Disclosed are compounds of formula (I) and formula (II): wherein R, R, A, and B are as defined herein. Also disclosed is a method of blocking transmission of aparasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.