The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Sep. 25, 2020
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Richard T. Lewis, Missouri City, TX (US);
Matthew Michael Hamilton, Missouri City, TX (US);
William J. Ray, Houston, TX (US);
Fernando Alvarez, Austin, TX (US);
Dana E. Pfaffinger, Houston, TX (US);
Naphtali Reyna, Arlington, TX (US);
Jason Cross, Pearland, TX (US);
Suyambu Kesava Vijayan Ramaswamy, Houston, TX (US);
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/06 (2006.01); A61K 31/4965 (2006.01); A61K 31/415 (2006.01); A61K 31/416 (2006.01); C07D 231/56 (2006.01); C07D 403/12 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 401/14 (2006.01); A61K 31/4439 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01); C07D 403/08 (2006.01); A61K 31/4155 (2006.01); C07D 413/08 (2006.01); A61K 31/4245 (2006.01); A61K 31/4184 (2006.01); C07D 207/10 (2006.01); A61K 31/40 (2006.01); A61K 31/4015 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); A61K 31/497 (2006.01); A61K 31/4192 (2006.01); C07D 487/04 (2006.01); A61K 31/4985 (2006.01); C07D 417/14 (2006.01); A61K 31/427 (2006.01); C07D 241/24 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 231/06 (2013.01); A61K 31/40 (2013.01); A61K 31/4015 (2013.01); A61K 31/415 (2013.01); A61K 31/416 (2013.01); A61K 31/4155 (2013.01); A61K 31/4184 (2013.01); A61K 31/4192 (2013.01); A61K 31/427 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 207/10 (2013.01); C07D 231/56 (2013.01); C07D 241/24 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/08 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/08 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract
Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.