The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Jun. 29, 2018
Massachusetts Institute of Technology, Cambridge, MA (US);
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Jeremiah A. Johnson, Boston, MA (US);
Hung Vanthanh Nguyen, Braintree, MA (US);
Andrzej Rajca, Lincoln, NE (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Abstract
Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-fieldH MRI techniques.