The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Nov. 30, 2020
Applicant:
Calder Biosciences Inc., New York, NY (US);
Inventor:
Christopher Patrick Marshall, New York, NY (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 38/16 (2006.01); C07K 14/005 (2006.01); C12P 21/00 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
A61K 38/162 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12P 21/00 (2013.01); G01N 33/56988 (2013.01); C12N 2740/16051 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.