The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Jan. 04, 2018
Nova Southeastern University, Fort Lauderdale, FL (US);
Sabanci Üniversitesi, Tuzla/Istanbul, TR;
Tolga Sutlu, Tuzla/Istanbul, TR;
Adil Doganay Duru, Fort Lauderdale, FL (US);
Batu Erman, Tuzla/Istanbul, TR;
NOVA SOUTHEASTERN UNIVERSITY, Fort Lauderdale, FL (US);
SABANCI ÜNIVERSITESI, Tuzla/Istanbul, TR;
Abstract
The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR a and β chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).