The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Dec. 16, 2019
Applicant:
Athenex HK Innovative Limited, Sha Tin, HK;
Inventors:
Min-Fun Rudolf Kwan, Summit, NJ (US);
E. Douglas Kramer, Stamford, CT (US);
David Lawrence Cutler, Moorestown, NJ (US);
Johnson Yiu-Nam Lau, Houston, TX (US);
Wing Kai Chan, Hong Kong, CN;
Assignee:
Athenex HK Innovative Limited, Sha Tin, HK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/435 (2006.01); A61K 31/4745 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/435 (2013.01); A61K 31/4745 (2013.01); A61P 35/00 (2018.01);
Abstract
The present disclosure provides pharmaceutical combinations of orally administered irinotecan and a P-gp inhibitor. The pharmaceutical combinations are suitable for the treatment of cancer in a subject and for reducing or preventing toxicity, hypersensitivity-type infusion reactions, and other negative outcomes resulting from or associated with intravenously administered irinotecan (e.g., Camptosar®) therapy in a subject suffering from cancer.