The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2023

Filed:

Jul. 29, 2022
Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Donhee Ham, Cambridge, MA (US);

Jeffrey T. Abbott, Cambridge, MA (US);

Wenxuan Wu, Cambridge, MA (US);

Tianyang Ye, Cambridge, MA (US);

Han Sae Jung, Cambridge, MA (US);

Hongkun Park, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/487 (2006.01); B01L 3/00 (2006.01); G01N 15/10 (2006.01); G01N 33/50 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/48728 (2013.01); B01L 3/502715 (2013.01); G01N 15/1031 (2013.01); G01N 33/5005 (2013.01); B01L 2300/0645 (2013.01); G01N 2015/0065 (2013.01);
Abstract

Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.


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