The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2023

Filed:

Jun. 16, 2016
Applicant:

Aspect Biosystems Ltd., Vancouver, CA;

Inventors:

Simon Beyer, Richmond, CA;

Tamer Mohamed, Richmond, CA;

Sheng Pan, Vancouver, CA;

Sam Wadsworth, Vancouver, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/077 (2010.01); C12M 1/12 (2006.01); G01N 33/50 (2006.01); B33Y 80/00 (2015.01); B33Y 70/00 (2020.01); C12M 1/26 (2006.01); C12M 3/00 (2006.01); B29C 64/118 (2017.01); B33Y 10/00 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0697 (2013.01); B29C 64/118 (2017.08); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); C12M 21/08 (2013.01); C12M 25/14 (2013.01); C12M 33/00 (2013.01); C12N 5/0658 (2013.01); G01N 33/5061 (2013.01); B33Y 10/00 (2014.12); C12N 2533/50 (2013.01);
Abstract

Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.


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