The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2023

Filed:

Dec. 11, 2020
Applicants:

Sharan Ramaswamy, Miami, FL (US);

Manuel Perez, Miami, FL (US);

Yih-mei Lin, Miami, FL (US);

Inventors:

Sharan Ramaswamy, Miami, FL (US);

Manuel Perez, Miami, FL (US);

Yih-Mei Lin, Miami, FL (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); A61K 9/00 (2006.01); A61K 35/28 (2015.01); C07K 14/765 (2006.01); C07K 14/47 (2006.01); A61P 9/10 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0663 (2013.01); A61K 9/0019 (2013.01); A61K 35/28 (2013.01); A61P 9/10 (2018.01); C07K 14/47 (2013.01); C07K 14/4717 (2013.01); C07K 14/765 (2013.01); C12N 2521/00 (2013.01); C12N 2533/40 (2013.01); C12N 2533/92 (2013.01);
Abstract

This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.


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