The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Dec. 10, 2021
Applicant:
Hadasit Medical Research Services and Development Ltd., Jerusalem, IL;
Inventors:
Benjamin Eithan Reubinoff, Doar-Na HaEla, IL;
Orna Singer, Jerusalem, IL;
Assignee:
Hadasit Medical Research Services and Development Ltd., Jerusalem, IL;
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/079 (2010.01); A61P 27/02 (2006.01); A61K 9/00 (2006.01); A61K 35/30 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0621 (2013.01); A61K 9/0051 (2013.01); A61K 35/30 (2013.01); A61P 27/02 (2018.01); C12N 2500/38 (2013.01); C12N 2501/115 (2013.01); C12N 2501/15 (2013.01); C12N 2502/13 (2013.01); C12N 2506/02 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01);
Abstract
A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.