The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Mar. 14, 2018
Applicant:
Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);
Inventors:
Steven David Goodman, Hilliard, OH (US);
Lauren O. Bakaletz, Hilliard, OH (US);
Assignee:
Research Institute at Nationwide Children's Hospital, Columbus, OH (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/52 (2006.01); A61P 31/04 (2006.01); A01N 63/50 (2020.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/52 (2013.01); A01N 63/50 (2020.01); A61K 38/19 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01);
Abstract
Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more modified HMG-box 1 domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.