The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
May. 30, 2018
King's College London, London, GB;
Secretary of State for Health and Social Care, London, GB;
Khondaker Mirazur Rahman, London, GB;
Shirin Jamshidi, London, GB;
Mark Benjamin Laws, London, GB;
Kazi Nahar, London, GB;
John Mark Sutton, Salisbury, GB;
Charlotte Hind, Salisbury, GB;
King's College London, London, GB;
Secretary of State for Health and Social Care, London, GB;
Abstract
The invention relates to antibiotic compounds of formula (A1) and pharmaceutically acceptable salts, solvates, tautomers and combinations thereof, wherein X and L are optional linkers and one of Ror Rcomprises Ar, wherein Aris an antibiotic resistance breaker moiety which comprises an optionally substituted Caryl, Caralkyl, Cheteroaryl, Cheteroaralkyl, Cheterocyclyl, Cheterocyclalkyl, Ccarbocyclyl, Ccarbocyclalkyl, —C(═NR')—NR′R″ or —CH—CH═CHgroup; wherein after administration of the compound to a bacterial infection this moiety reduces or prevents efflux. The invention also discloses pharmaceutical compositions comprising compounds of formula (A1) and the use of such compounds as medicaments, in particular, to treat bacterial infections, such as drug-resistant bacterial infections.