The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Sep. 28, 2021
Applicants:
Creighton University, Omaha, NE (US);
St. Jude Children's Research Hospital, Inc. (Tennessee Not for Profit Corporation), Memphis, TN (US);
Inventors:
Jian Zuo, Omaha, NE (US);
Santanu Hati, Omaha, NE (US);
Marisa Laura Zallocchi, Omaha, NE (US);
Robert Hazlitt, Boulder, CO (US);
Jaeki Min, Memphis, TN (US);
Assignees:
CREIGHTON UNIVERSITY, Omaha, NE (US);
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (TENNESSEE NOT FOR PROFIT CORPORATION), Memphis, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); A61P 27/16 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08); A61K 47/545 (2017.08); A61P 27/16 (2018.01);
Abstract
Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.