The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Jul. 23, 2021
Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
California Institute of Technology, Pasadena, CA (US);
The Regents of the University of California, Oakland, CA (US);
Brittany D. Needham, Pasadena, CA (US);
Sarkis K. Mazmanian, Pasadena, CA (US);
Gil Sharon, Pasadena, CA (US);
Masanori Funabashi, San Francisco, CA (US);
Michael A. Fischbach, San Francisco, CA (US);
Elaine Y. Hsiao, Pasadena, CA (US);
Paul H. Patterson, Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.