The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Dec. 10, 2018
Applicant:
General Oncology, Inc., Brookline, MA (US);
Inventor:
Arnold Glazier, Newton, MA (US);
Assignee:
General Oncology, Inc., Brookline, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/138 (2006.01); A61P 35/00 (2006.01); A61K 31/704 (2006.01); A61K 31/175 (2006.01); A61K 31/198 (2006.01); A61K 31/5377 (2006.01); A61K 31/69 (2006.01); A61K 35/28 (2015.01); A61K 38/05 (2006.01); A61K 38/07 (2006.01);
U.S. Cl.
CPC ...
A61K 31/704 (2013.01); A61K 31/138 (2013.01); A61K 31/175 (2013.01); A61K 31/198 (2013.01); A61K 31/5377 (2013.01); A61K 31/69 (2013.01); A61K 35/28 (2013.01); A61K 38/05 (2013.01); A61K 38/07 (2013.01);
Abstract
The present invention relates to methods for the treatment of metastatic cancer. Methods of treating metastatic cancer by administration of a set of drugs overcome multiple mechanisms of melphalan resistance and hypersensitize cancer cells to melphalan are described. The methods involve the administration of drug(s) that induce oxidative stress in cancer cells, in conjunction with melphalan on a defined schedule.