The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Jan. 14, 2020
Applicant:
Chemocentryx, Inc., Mountain View, CA (US);
Inventors:
Israel Charo, Mountain View, CA (US);
Heiyoun Jung, Menlo Park, CA (US);
Thomas J. Schall, Menlo Park, CA (US);
Penglie Zhang, Foster City, CA (US);
Assignee:
CHEMOCENTRYX, INC., Thousand Oaks, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 31/4192 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 31/4178 (2006.01); A61K 31/496 (2006.01); A61K 39/395 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4192 (2013.01); A61K 9/0053 (2013.01); A61K 31/4178 (2013.01); A61K 31/496 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/2827 (2013.01); C07K 16/3015 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention provides methods for reducing tumor burden, tumor growth, tumor progression, and/or metastasis in a subject suffering from a solid tumor cancer such as triple negative breast cancer. The methods include administering to a subject in need thereof a therapeutically effective amount of a PD-L1 inhibitor or a PD-1 inhibitor in combination with a small molecule chemokine receptor antagonist that blocks CCR1.