The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Nov. 06, 2017
Centro DE Investigación Biomédica En Red (Ciber-isciii), Madrid, ES;
Fundación Incliva, Valencia, ES;
Universitat DE València Estudi General, Valencia, ES;
José Luis García Giménez, Valencia, ES;
Carlos Romá Mateo, Valencia, ES;
Federico V. Pallardó Calatayud, Valencia, ES;
Centro de Investigación Biomédica en Red (CIBER-ISCIII), Madrid, ES;
Fundación INCLIVA, Valencia, ES;
Universitat de Valencia Estudi General, Valencia, ES;
Abstract
The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.