The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Apr. 10, 2019
Applicant:
Ottawa Hospital Research Institute, Ottawa, CA;
Inventors:
Carolina Solange Ilkow, Ottawa, CA;
John Cameron Bell, Ottawa, CA;
Victoria Ann Maher, Leeds, GB;
Briana Livia Rollande Samson, Morriston, CA;
Assignee:
OTTAWA HOSPITAL RESEARCH INSTITUTE, Ottawa, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/87 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/87 (2013.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/531 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present disclosure provides a miRNA hairpin that, when processed by a virus-infected cell, increases the therapeutic effectiveness of the virus. The present disclosure also provides a virus encoding such a miRNA hairpin. The present disclosure also provides pre-miRNAs that, when processed by a virus-infected cell, increase extracellular vesicle secretion of the encoded miRNA hairpin by the virus-infected cell.