The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
May. 14, 2020
Applicant:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventors:
Hiroshi Iwata, Brookline, MA (US);
Masanori Aikawa, Chestnut Hill, MA (US);
Takuya Hara, Fuji, JP;
Sasha Singh, Boston, MA (US);
Piero Ricchiuto, Milan, IT;
Hideo Yoshida, Brookline, MA (US);
Iwao Yamada, Boston, MA (US);
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/519 (2013.01); C12N 2310/14 (2013.01); C12Y 204/0203 (2013.01);
Abstract
The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies.