The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Mar. 18, 2020
Applicant:
Innovative Cellular Therapeutics Holdings, Ltd., Grand Cayman, KY;
Inventors:
Assignee:
Innovative Cellular Therapeutics Holdings, Ltd., George Town, KY;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C12N 5/0783 (2010.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70521 (2013.01); C07K 14/7051 (2013.01); C07K 16/30 (2013.01); C12N 5/0636 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01);
Abstract
Embodiments relate to a modified cell comprising a chimeric antigen receptor (CAR) and a dominant negative form of PD-1, wherein the dominant negative form of PD-1 lacks a functional PD-1 intracellular domain for PD-1/PD-L1 signal transduction, and the CAR comprises an antigen binding domain, a transmembrane domain, a co-stimulatory domain, and a CD3 zeta domain. The dominant negative form of PD-1 is regulated by an inducible gene expression system.