The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Feb. 23, 2021
Gwo Xi Stem Cell Applied Technology Co., Ltd., Zhubei, TW;
Ming-Hsi Chuang, Zhubei, TW;
Lin-Hsiang Chuang, Zhubei, TW;
Ming-Hsuan Lu, Zhubei, TW;
Wen-Peng Shen, Zhubei, TW;
Yun-Chen Lin, Zhubei, TW;
Chi-Hsuan Chuang, Zhubei, TW;
GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD., Zhubei, TW;
Abstract
The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.