The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2023

Filed:

Sep. 28, 2018
Applicants:

F. Hoffmann-la Roche Ag, Basel, CH;

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Markus Hemminger, Basel, CH;

Ulla Grauschopf, Basel, CH;

Frank Bamberg, Basel, CH;

Mayumi Bowen, South San Francisco, CA (US);

Robert Müller, Basel, CH;

Flora Felsovalyi, Basel, CH;

Denny Christensen, South San Francisco, CA (US);

Assignees:

F. HOFFMANN-LA ROCHE AG, Basel, CH;

GENENTECH, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 2/00 (2006.01); A61L 11/00 (2006.01); A61L 2/20 (2006.01); A61M 5/00 (2006.01); A61M 5/31 (2006.01); A61M 5/315 (2006.01); A61M 5/32 (2006.01); B65B 3/00 (2006.01); B65B 7/28 (2006.01); B65B 55/10 (2006.01); B65B 55/02 (2006.01);
U.S. Cl.
CPC ...
A61L 2/206 (2013.01); A61M 5/001 (2013.01); A61M 5/002 (2013.01); A61M 5/315 (2013.01); A61M 5/3129 (2013.01); A61M 5/3202 (2013.01); B65B 3/003 (2013.01); B65B 7/2821 (2013.01); B65B 55/10 (2013.01); A61L 2202/23 (2013.01); A61L 2202/24 (2013.01); A61M 5/31513 (2013.01); A61M 2005/3104 (2013.01); A61M 2005/3114 (2013.01); A61M 2205/0238 (2013.01); A61M 2207/00 (2013.01); A61M 2207/10 (2013.01); B65B 55/02 (2013.01);
Abstract

A method of preparing a prefilled syringe is disclosed that includes obtaining a syringe barrel and a needle adaptor cap assembled on the tip of the syringe barrel, wherein the needle adaptor cap has a rubber element tightly sealing the orifice of the tip of the syringe barrel and the syringe barrel together with the needle adaptor cap assembled on the tip of the syringe barrel is sterilized by a first sterilizing. Filling a drug substance into an interior of the syringe barrel and sealing the interior of the syringe barrel. Packaging the syringe barrel with a rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel. Providing a second external surface sterilizing of the packaged syringe barrel with the rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel.


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