The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2023

Filed:

Nov. 17, 2022
Applicant:

Imam Abdulrahman Bin Faisal University, Dammam, SA;

Inventors:

Sarah Mousa Asiri, Dammam, SA;

Firdos Alam Khan, Dammam, SA;

Ayhan Bozkurt, Dammam, SA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 47/6923 (2017.08); A61K 47/545 (2017.08); A61K 47/6935 (2017.08); A61P 35/00 (2018.01); B82Y 5/00 (2013.01);
Abstract

A combination therapy involving different therapeutic molecules can enhance and improve the therapeutic potentials. An effective therapeutic strategy conjugates silica (SiO) nanoparticles with, e.g., 3-glycidyloxypropyl, trimethoxysilane and azoles, e.g., 1,2,4-triazole (Tri), 3-aminotriazole (ATri), 5-aminetetrazole (Atet), imidazole (Imi). These exemplary materials—classified as SiO-3GPS-Tri (Conj. 1), SiO-3GPS-Atri (Conj. 2), SiO-3GPS-Atet (Conj. 3), SiO-3GPS-Btri (Conj. 4), and SiO-3GPS-Imi (Conj. 5)—can amplify targeting of therepeutics for human colorectal carcinoma cells (HCT-116), enhancing anti-cancer effects.


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