The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
May. 24, 2018
Sib Swiss Institute of Bioinformatics, Lausanne, CH;
Chuv—centre Hospitalier Universitaire Vaudois, Lausanne, CH;
Universite DE Lausanne, Lausanne, CH;
Ludwig Institute for Cancer Research Ltd, Zurich, CH;
Olivier Michielin, Lausanne, CH;
Vincent Zoete, Morges, CH;
George Coukos, Chexbres, CH;
Melita Irving, Prilly, CH;
Nahzli Dilek, Collombey, CH;
Patrick Reichenbach, La Sarraz, CH;
Kelly Ascencao, Prilly, CH;
SIB Swiss Institute of Bioinformatics, Lausanne, CH;
CHUV—Centre Hospitalier Universitaire Vaudois, Lausanne, CH;
Université de Lausanne, Lausanne, CH;
Ludwig Institute for Cancer Research Ltd, New York, NY (US);
Abstract
The present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, methods of reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.