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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11735289 B1

PDFFull Text
Date of Patent:
Aug. 22, 2023

Filed:

Jan. 16, 2019

Method and system for analyzing metabolic state of a cell by measuring concentrations of metabolites

Applicant:

Tata Consultancy Services Limited, Mumbai, IN;

Inventors:

Sharmila Shekhar Mande, Pune, IN;

Arvind J Shankar, Pune, IN;

Tungadri Bose, Pune, IN;

Anirban Dutta, Pune, IN;

Assignee:

TATA CONSULTANCY SERVICES LIMITED, Mumbai, IN;

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner LLP

Primary Examiner:

Anna Skibinsky

Int. Cl.
CPC ...
G01N 33/48 (2006.01); G16B 5/20 (2019.01); G16B 5/00 (2019.01);
U.S. Cl.
CPC ...
G16B 5/20 (2019.02); G16B 5/00 (2019.02);
Abstract

Analysis of the flow of fluxes through the metabolic network of a cell type is useful in gaining knowledge about cellular physiology. Such knowledge can be used in understanding host's interactions with pathogens, drug response etc. However there is dearth of techniques that can incorporate metabolomics data into genome scale metabolic model (GEM) for FBA. A method and system for analyzing metabolic state of a cell at a genome scale by measuring concentrations of a one or more metabolites has been disclosed. The method is utilizing intracellular and/or extracellular metabolite concentrations for constraining reaction fluxes in FBA by incorporating it as part of stoichiometric constraint to metabolic model. The method is used to predict the change in flux flow through all reactions in an organism/cell type under different experimental conditions. The method enables constraining the flow of fluxes through reactions while performing FBA of GEMs using measured metabolite concentrations.

Find Patent Forward Citations

Mande, Sharmila. (2023). Method and system for analyzing metabolic state of a cell by measuring concentrations of metabolites (U.S. Patent No. 11735289). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11735289

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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