The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Oct. 26, 2020
Amgen Inc., Thousand Oaks, CA (US);
Michael Ollmann, San Carlos, CA (US);
Yang Li, Mountain View, CA (US);
Jun Zhang, Foster City, CA (US);
Oliver Homann, Berkeley, CA (US);
Leslie P. Miranda, Thousand Oaks, CA (US);
Justin K. Murray, Moorpark, CA (US);
Bin Wu, Thousand Oaks, CA (US);
Oh Kyu Yoon, Pacifica, CA (US);
John Gordon Allen, Newbury Park, CA (US);
Chawita Netirojjanakul, Longmont, CO (US);
Yuan Cheng, Newbury Park, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.