The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Oct. 05, 2020
Hoffmann—la Roche, Inc., Little Falls, NJ (US);
Centre Leon Berard, Lyons, FR;
Universite Claude Bernard Lyon I, Villeurbanne, FR;
Centre National DE LA Recherche Scientifique, Paris, FR;
Inserm—institut National DE LA Sante ET DE LA Recherche Medicale, Paris, FR;
Souphalone Luangsay, Basel, CH;
Barbara Testoni, Lyons, FR;
Fabien Zoulim, Lyons, FR;
Soren Ottosen, Horsholm, DK;
Lykke Pedersen, Horsholm, DK;
Other;
Abstract
The present invention relates to a FUBP1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of FUBP1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules, such as oligonucleotides including siRNA, shRNA and antisense oligonucleotides, which are complementary to FUBP1 and capable of reducing a FUBP1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.