The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Mar. 01, 2019
Applicants:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
Inventors:
Frank Rigo, Carlsbad, CA (US);
Michelle L. Hastings, North Chicago, IL (US);
Assignees:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/32 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/346 (2013.01); C12N 2320/33 (2013.01);
Abstract
Certain embodiments disclosed herein are directed to compounds and methods for modulating APP expression. In certain embodiments, modulating the splicing of amyloid precursor protein (APP) reduces amyloid β (Aβ) production.