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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11732012 B1

PDFFull Text
Date of Patent:
Aug. 22, 2023

Filed:

Sep. 24, 2020

Attenuated strains of oncolytic rhabdovirus and uses thereof in tumor treatment

Applicant:

Hangzhou Everbright Biologics, Ltd., Zhejiang, CN;

Inventors:

Frank XiaoFeng Qin, Jiangsu, CN;

Jing Xia, Jiangsu, CN;

Assignee:

FANTASIA BIOPHARMA (ZHEJIANG) CO. LTD., Zhejiang, CN;

Attorneys:

Innovar, L.L.C.

Rick Matos

Primary Examiner:

Nianxiang Zou

Int. Cl.
CPC ...
C07K 14/145 (2006.01); A61K 39/205 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/145 (2013.01); A61K 39/205 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 38/00 (2013.01); A61K 2039/525 (2013.01);
Abstract

Provided is a modified matrix protein of a vesicular stomatitis virus, wherein the protein has amino acid substitutions at position 21, position 51, position 111 and position 221. Further provided are an attenuated strain of the vesicular stomatitis virus producing the modified matrix protein, a composition containing the attenuated strain, and uses thereof in preparing a drug for killing abnormally proliferating cells, inducing and promoting antitumor immune response, or eliminating immunosuppression in a microenvironment of a tumor tissue.

Find Patent Forward Citations

Qin, Frank. (2023). Attenuated strains of oncolytic rhabdovirus and uses thereof in tumor treatment (U.S. Patent No. 11732012). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11732012

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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