The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Mar. 15, 2019
Glympse Bio, Inc., Cambridge, MA (US);
Sangeeta Bhatia, Lexington, MA (US);
Gabriel Kwong, Atlanta, GA (US);
Eric Huang, Lexington, MA (US);
Sirshendu Roopom Banerjee, Lexington, MA (US);
Andrew Warren, Cambridge, MA (US);
Sophie Cazanave, Cambridge, MA (US);
GLYMPSE BIO, INC., Cambridge, MA (US);
Abstract
A nanoparticle activity sensor containing a reporter and at least one tuning domain that modifies a distribution or residence time of the activity sensor when administered to a patient. When administered to the patient, the activity sensor enters cells or tissue where it is cleaved by enzymes specific to a physiological state such as a disease to release a detectable analyte. The tuning domains include molecular structures that modulate distribution or decay by protecting the particle from premature cleavage and indiscriminate hydrolysis, shielding the particle from immune detection and clearance, or by targeting the particle to specific tissue, bodily fluids, or cell types.