The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2023

Filed:

Aug. 14, 2018
Applicants:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;

Topharman Shanghai Co., Ltd., Shanghai, CN;

Inventors:

Yang He, Shanghai, CN;

Xiangrui Jiang, Shanghai, CN;

Jianfeng Li, Shanghai, CN;

Yu Wang, Shanghai, CN;

Zhen Wang, Shanghai, CN;

Weiming Chen, Shanghai, CN;

Fuqiang Zhu, Shanghai, CN;

Chunhui Wu, Shanghai, CN;

Rongxia Zhang, Shanghai, CN;

Jingshan Shen, Shanghai, CN;

Hualiang Jiang, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 455/03 (2006.01); C07D 498/14 (2006.01); A61P 25/20 (2006.01);
U.S. Cl.
CPC ...
C07D 455/03 (2013.01); A61P 25/20 (2018.01); C07D 498/14 (2013.01);
Abstract

The present invention provides a tetrahydroprotoberberine compound represented by the formula (I), enantiomers, diastereomers, racemates and mixtures thereof, and pharmaceutically acceptable salts, crystalline hydrates and solvates thereof. The invention also provides a method for preparing the compound and the use thereof in the preparation of a medicament for preventing and/or treating central nervous system diseases.


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