The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Jan. 11, 2019
Applicant:
Prolynx Llc, San Francisco, CA (US);
Inventors:
Daniel V. Santi, San Francisco, CA (US);
Shaun Fontaine, Concord, CA (US);
Assignee:
ProLynx LLC, San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/06 (2006.01); A61K 47/60 (2017.01); A61K 9/51 (2006.01); A61P 35/00 (2006.01); A61K 31/4745 (2006.01); A61K 45/06 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 51/065 (2013.01); A61K 9/51 (2013.01); A61K 31/4745 (2013.01); A61K 47/60 (2017.08); A61P 35/00 (2018.01); A61K 45/06 (2013.01); B82Y 5/00 (2013.01);
Abstract
Conjugates of topoisomerase I inhibitors linked to a macromolecule through a linkage that undergo beta elimination in situ in combination with one or more of an assessed defect in DNA damage response (DDR) in a subject bearing cancer, a cell cycle checkpoint inhibitor and/or a DDR inhibitor provides improved outcomes for cancer-bearing subjects.