The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Feb. 06, 2018
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/86 (2006.01); C07H 21/04 (2006.01); A61P 27/16 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61P 27/16 (2018.01); C07K 14/4716 (2013.01); C07K 14/705 (2013.01); C12N 15/86 (2013.01); C07H 21/04 (2013.01);
Abstract
Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. Some embodiments are directed to a synthetic inner ear hair cell targeting adeno-associated virus (AAV) vector, a cell comprising the synthetic inner ear hair cell targeting AAV vector, and method of treating Usher Syndrome in a subject using the synthetic inner ear hair cell targeting AAV vector.